how aspartame causes many breast cancers,

how aspartame causes many breast cancers, WC Monte, PhD


Diary Entry by Rich Murray


Aspartame is 11% methanol, which the body quickly makes into formaldehyde, especially in breast tissue, thus causing many cancers. The same level of methanol is also in dark wines and liquors. Woodrow C. Monte, PhD, is a retired Professor of Nutrition.

::::::::
old tiger roars -- Woodrow C Monte, PhD -- aspartame causes
many breast cancers, as ADH enzyme in breasts makes methanol
from diet soda into carcinogenic formaldehyde -- same in dark
wines and liquors, Fitness Life 2008 Jan.: Murray 2008.02.11
http://rmforall.blogspot.com/2008_02_01_archive.htm
Monday, February 11, 2008
http://groups.yahoo.com/group/aspartameNM/message/1517
____________________________________________________


"Every molecule of Aspartame releases a molecule of methanol
within minutes of being consumed. The first step in methanol
metabolism is production of formaldehyde. After the liver,
the next greatest concentration of Alcohol Dehydrogenase Enzyme
(ADH) in the human body is located in the endothelial tissue
of the human breast (190b). It is human ADH that converts
methanol into formaldehyde, a powerful carcinogen.

The charts below shows the relationship between Aspartame
consumption and the increase of breast cancer in the United States.
Similar increases in breast cancer (190) have occurred in other
aspartame consuming countries of the world."

"The methanol, always produced when Aspartame is consumed
(20, 51), will convert directly into formaldehyde -- there is no
intermediate compound or alternate path (7, 30).


role of formaldehyde, made by body from methanol from foods
and aspartame, in steep increases in fetal alcohol syndrome, autism,
multiple sclerosis, lupus, teen suicide, breast cancer, Nutrition
Prof. Woodrow C. Monte, retired, Arizona State U., two reviews,
190 references supplied, Fitness Life, New Zealand
2007 Nov, Dec: Murray 2007.12.26
http://rmforall.blogspot.com/2007_12_01_archive.htm
Wednesday, December 26 2007
http://groups.yahoo.com/group/aspartameNM/message/1498


Alcohol dehydrogenase ADH is required for the conversion of
methanol to formaldehyde (112).

ADH is not a common enzyme in the human body -- not many cells
in the human body contain this enzyme.

The human breast is one of the few organs in the body with a high
concentration of ADH (190b), and it is found there exclusively in the
mammary epithelial cells, the very cells known to transform into
adenocarcinoma (190c) (breast cancer).

The most recent breast cancer scientific literature implicates ADH
as perhaps having a pivotal role in the formation of breast cancer,
indicating a greater incidence of the disease in those
with higher levels of ADH activity in their breasts (190a)."

Aspartame consumption as a causative agent of Breast Cancer
Woodrow C. Monte Ph.D.
Professor of Food Science, Arizona State University (Retired)
Page, Arizona
woodymonte@canyoncountry.net;
202. Monte WC. Bittersweet: Aspartame Breast Cancer Link.
http://www.thetruthaboutstuff.com/review3.shtml
[ not online 2008.02.09 -- Rich Murray has corrected minor typos
and added spacing to increase readability of this seminal research. ]

It is a pleasure to be writing to a physician. The mechanism of
Aspartame poisoning is so much easier to explain to someone with
a medical background.

I am a retired Professor of Food Science from Arizona State
University. I have studied, researched and written about
Aspartame since 1983, shortly after its manufacturer applied to
the FDA to expand its use as an additive to soft drink beverages.
In 1984 I published a scientific paper warning of the potential harm
that Aspartame might cause by increasing the methanol consumption
of the unwary consumer (1).

I have within the last 3 months published 3 additional articles
chronicling, in detail, the aftermath of 27 years of Aspartame
poisoning of the general public (78, 194, 202).

These articles and all of the reference material that they draw on
are freely available on my website:
http://www.thetruthaboutstuff.com/

Article 1 http://www.thetruthaboutstuff.com/review1.shtml
Article 2 http://www.thetruthaboutstuff.com/review2.shtml
Article 3 http://www.thetruthaboutstuff.com/review3.shtml
[ the third not active as of 2008.02.11 ]

Every molecule of Aspartame releases a molecule of methanol
within minutes of being consumed. The first step in methanol
metabolism is production of formaldehyde. After the liver,
the greatest concentration of Alcohol Dehydrogenase Enzyme
(ADH) in the human body is located in the endothelial tissue
of the human breast (190b). It is human ADH that converts
methanol into formaldehyde, a powerful carcinogen.

The charts below shows the relationship between Aspartame
consumption and the increase of breast cancer in the United States.
Similar increases in breast cancer (190) have occurred in other
aspartame consuming countries of the world.

[ Breast Cancer A
http://www.thetruthaboutstuff.com/charts/
Breast%20Cancer%20USA%20A.pdf

Breast Cancer B
http://www.thetruthaboutstuff.com/charts/
Breast%20Cancer%20USA%20B.pdf ]

Formaldehyde is a powerful cancer causing agent, one of the
handful of chemicals classed as a Group I carcinogen by the
IARC, the International Agency for Research on Cancer,
Lyon, France (11) -- because of this, there is no known safe level
of formaldehyde exposure.

Formaldehyde from contaminated air, at very low
concentrations (11), causes cancer in humans.

Gaseous environmental formaldehyde causes nasopharyngeal
cancer -- however, it is not known, in the gaseous form, to cause
breast cancer.

The probable reason for this is that formaldehyde has an extremely
high reactivity (201) -- it reacts with and does its damage to the
first human tissue with which it makes contact. Formaldehyde
does not travel well in protein rich blood supply (122),
and because of this it is blocked from reaching the breast
and other internal organs.

The only way that formaldehyde can reach the mammary tissue,
aside from purposely injecting formaldehyde solution (122)
(as in embalming) is to disguise the formaldehyde as methanol.

The methanol from Aspartame can reach a woman's breast, and
will there be readily converted into formaldehyde by ADH (190b).

[ 190a. Coutelle C. et al. 2004.
Risk Factors in Alcohol Associated Breast Cancer:
Alcohol Dehydrogenase Polymorphism and Estrogens.
International Journal of Oncology 25: 1127-1132

190b. Triano E. A. et al. 2003.
Class I Alcohol Dehydrogenase Is Highly Expressed in Normal
Human Mammary Epithelium but not in Invasive Breast Cancer: Implications for
Breast Carcinogenesis.
Cancer Research Arch. 63: 3092-3100

190c. Poschl G. and Seitz H. K. 2004.
Alcohol and Cancer (Review).
Alcohol & Alcoholism. 39(3): 155-165 ]

It is not possible to prevent Aspartame from producing the cancer
causing compound formaldehyde in a woman's breast (78).
All of the methanol in diet soda must be transformed into
formaldehyde before the body can metabolize it.

The scientifically acclaimed Ramazzini Institute recently found
consumption of Aspartame over time caused Breast Cancer
in Rats (50).

The methanol that is responsible for producing this formaldehyde
is also found in our processed food supply -- the average modern
woman not exposed to diet products consumes, conservatively,
less than 8 milligrams of it a day (1).

One can of diet soda contains about 4 times this amount,
one liter [ almost 6 cans ] 20 times the average.

Primitive and or impoverished women consume little methanol,
and so are protected, to a very great extent, from breast cancer.
Conversely, increased consumption of Aspartame has caused breast cancer
rates to increase dramatically (194).

[ Methanol and formaldehyde sources include dark wines and
liquors, tobacco and wood smoke, vehicle exhaust, medical
facilities, dental materials, embalming, common cleaners and
personal care products, new carpet, drapes, furniture,
particleboard, new mobile homes and buildings, new cars,
some foreign fish and foods, and leather. ]

It can be shown that the incidence of breast cancer has increased
dramatically in populations exposed to Aspartame (194).
The breast is an organ with no way to protect itself from
formaldehyde and with no means to render it harmless.

The methanol, always produced when Aspartame is consumed
(20, 51), will convert directly into formaldehyde -- there is no
intermediate compound or alternate path (7, 30).

Alcohol dehydrogenase ADH is required for the conversion of
methanol to formaldehyde (112).

ADH is not a common enzyme in the human body -- not many
cells in the human body contain this enzyme.

The human breast is one of the few organs in the body with a high
concentration of ADH (190b), and it is found there exclusively in the
mammary epithelial cells, the very cells known to transform into
adenocarcinoma (190c) (breast cancer).

The most recent breast cancer scientific literature implicates ADH
as perhaps having a pivotal role in the formation of breast cancer,
indicating a greater incidence of the disease in those with higher
levels of ADH activity in their breasts (190a).

One article went so far as to implicate acetaldehyde as a potential
culprit (190a). Acetaldehyde is the molecule that ethanol is
metabolized into by ADH, the first step in the manufacture of
vinegar, a beneficial molecule with no link to carcinogenicity,
whatsoever.

Recent scientific literature is a desert when it comes to methanol.
It is as if there were no such thing as methanol in the environment,
or as if methanol did not exist -- as if all the laboratories doing work
in methanol toxicity had vanished from the face of the earth 40
years ago and with them the science of methanol poisoning (39).

The truth is that methanol acts as a golden bullet, wasting none of its
destructive power, but administering a carcinogen directly inside
those breast cells most vulnerable to cancer.

All of the hundreds of test that were done to prove Aspartame safe
were done on animals insensitive to methanol poisoning (78).
This was well known to the company who invented Aspartame --
why else would they have hired the world's methanol research
laboratories to help them prove aspartame was safe (39)?
These animals have a specialized catalase enzyme in their livers
that humans do not (55). Catalase keeps methanol out of their
general circulation and therefore they are mostly immune to
methanol as a poison.

Many thousands of people lost their lives in the early nineteen
hundreds when methanol was allowed in foods and medications
after it was proven falsely safe by trusting methanol safety testing
done on an identical array of animals (17, 30).

Twenty six years ago, I traveled from my laboratory at Arizona
State University to Washington DC to view the results of the
testing done by the company who invented Aspartame and were
seeking its approval for use in carbonated beverages.

I will never forget viewing the data from the only high dosage
human consumption study done on diabetics. This study was never
to be repeated. Before the test began the subjects were screened
for all manner of illnesses and certified disease free (save from
diabetes) as a prerequisite to being accepted into the study.

During that study, after 11 weeks of high dose aspartame
consumption, two of the women developed epithelial cancer.
Both were removed from the study, one had a mastectomy,
subsequent pathology tested conclusively for adenocarcinoma.

To my most profound horror, the executive summary of that study concluded
that Aspartame was safe! The rational used to ignore
the fact that none of the placebo group but fully 8% of the
Aspartame consumption subjects developed epithelial cancer
during the high dosage consumption study was that
"no such cancers were seen in the numerous animal studies" (48).

[ 48. Anonymous1994.
Aspartame for use as a Sweetener in Carbonated Beverages.
Searle Research and Development.
Petition submitted to the United States Food and Drug
Administration -- FAP 2A3661 ]

The Bressler Report exposed that this was a lie (197).
These cancers should have never been ignored.

I can not say that methanol is the only cause of breast cancer, as
there are so many other poisons in our modern environment.
I will say that it is intuitively obvious that there would be no good
done producing one more cancer causing agent inside a sensitive
breast cell already exposed to other cancer causing agents.



64 retired married hospice care giver, enlightenment, all sciences, world Internet democracy, good and safe food, drink, environment
"Of course, everyone chooses, as a natural priority,
to actively find, quickly share, and positively act upon
the facts about healthy and safe food, drink, and
environment."